Granulomatosis ea Wegener ke boloetse bo ikemetseng bo bolelang mafu a maholo le a potlakileng a tsoelang pele. Ma- vasculitis a tloaelehileng le granulomatosis ea Wegener ke mafu a amanang haholo-holo, hobane li-antibodies (antineutrophil cytoplasmic) li thehoa ka granulomatosis, e leng se khetholloang ke vasculitis e amanang le ANCA.
Lisosa tsa granulomatosis ea Wegener
Granulomatosis ea Wegener e bolela ho ipapisa le 'mele, kahoo ho ka' na ha e-ba le liphatsa tsa lefutso. Ha e le hantle, granulomatosis ha e na matla a ho itšireletsa mafung. Kahoo, matšoao a lefu lena ke li-antigen - HLA 〖B〗 _7, B_8, 〖DR〗 _2, 〖DQ〗 _w7.
Karolo ea likokoana-hloko e boetse e bapaloa ke li-antibodies tse nang le likokoana-hloko tse sebetsanang le proteinase-3.
Granulomatosis ea Wegener - matšoao
Matšoao a granulomatosis a atisa ho etsahala ha a le lilemo li 40, athe taba ea bong bo sa tsotellehe.
Granulomatosis - ho ruruha ha marako a lijana tse nyenyane le tse mahareng: likokoana-hloko, li-capillaries, methapo ea methapo le arterioles. Nakong ea ho hlōloa, karolo e ka holimo ea phefumoloho, liphio, mahlo, matšoafo le litho tse ling li ameha.
Matsoao ke a latelang:
- kakaretso - tahlehelo ea boima ba 'mele, bofokoli, myalgia, arthralgia, fever, maemong a sa tloaelehang, ramatiki;
- tsamaiso ea methapo ea mali - e se nang phekolo ea polyneuropathy;
- mahlo-ischemia ea methapo ea optic, bofofu, episcleritis le granuloma ea orbital le exophthalmos;
- letlalo - ho qhibiliha ka likarolo tse nyenyane;
- liphio- glomerulonephritis , e ka nka thupelo e potlakileng;
- matšoafo - lisele li hlahisa bakuli ba 75% ka mokhoa oa infiltrates, e leng mekhoa e metso nakong ea ho bola; 'me sena se ka hlokomeloa pleurisy, khohlela.
- lipapitšana tsa phefumoloho - li amehile ho bakuli ba 90% ka mokhoa oa ho rhinitis ka ho boloka likokoana-hloko tsa haemorrhagic le seso; ho phunyeha ha nasal septum ho lebisa ho sesebelisoa; Hape, leqeba le ama mesifa, litsebe, litchechea, libe tsa paranasal, tseo ho tsona ho etsoang mokhoa oa ho ba le methapo.
Granulomatosis ea Wegener e boetse e na le mefuta e 'meli:
- e fumaneha sebakeng sa heso - e ama haholo-holo pampitšana e ka holimo ea ho hema;
- ka kakaretso - le eena makala a mangata a amehile, 'me sena se tsamaisana le feberu, mahlaba-mahlo a kopantsoeng, ho khohlela le ho hloleha ha pelo.
Ho lemoha ha granulomatosis ea Wegener
Tlhahlobo ena e entsoe ke rheumatologist e thehiloeng ho data e 'maloa:
- liteko tsa mali - likokoana-hloko le tse tloaelehileng, tse ke keng tsa tiisa granulomatosis, empa li thusa ho laola maloetse a mang;
- tlhahlobo ea moroto - e khona ho netefatsa kapa ho qoba tšenyo ea liphio (mofuta oa lefu lena o ikemiselitse);
- X-ray ea sinus ea paranasal le thorax (computed tomography e fana ka boitsebiso bo qaqileng ho feta bo fumanoang ke X-ray);
- biopsy - tsela e le 'ngoe feela e tiisang kapa e hanang boteng ba granulomatosis; lingaka li nka lisele ka mpong kapa methapong, 'me maemong a mang, liphio le matšoafo.
Phekolo ea granulomatosis ea Wegener
Phekolo ea lefu lena e etsoa, haholo-holo, ka kabelo ea corticosteroids le cytostatics, e fokotsang mosebetsi
Ka tšenyo e matla ea liphio, maemong a mang, mokuli o hloka setho sa 'mele.
Granulomatosis ea Wegener - prognosis
Haeba kalafo e sa qaloa ka nako e loketseng, joale ho hlajoa hampe ho tla etsahala nakong ea likhoeli tse 6-12, 'me karolelano ea bophelo e ke ke ea feta likhoeli tse 5.
Tabeng ea phekolo, phetoho e nka lilemo tse ka bang 4, maemong a mang lilemo tse 10. Pheko e phethehileng hona joale ea tsoelo-pele ea meriana ha e khonehe.