Thrombocytopenia ke bofokoli bo fokolang ba liplatelete tsa lipilisi (platelet). Lisele tsena tsa mali tse se nang 'mala li bohlokoa haholo bakeng sa ho koala mali. Ho boleloa hore thrombocytopenia e ka beha bophelo kotsing, hobane e baka tšollo ea mali le ho tsoa mali ka ntle ho litho.
Lisosa tsa thrombocytopenia e ikemetseng
Lisosa tsa thrombocytopenia li fapane haholo. Ho hloka li-platelet ho ka etsahala ka lebaka la mathata a ho itšireletsa ka tšelo ea mali, e sa lumellaneng le litho tsa sehlopha, kapa ha antigen e tsoang linaheng tse ling e kena 'meleng, ka mohlala, kokoana-hloko. Empa khafetsa hangata 'meleng oa motho, autommune thrombocytopenia e qala. Ena ke boemo boo sesole sa 'mele sa' mele se sa tsebeng "platelet sa eona se phetseng hantle, se lebisang ho nts'etsopele ea li-antibodies ho felisa" mojaki ". Haeba thrombocytopia e joalo e tsamaea le boloetse bo bong, joale e bitsoa sekondari. Lisosa tsa lona ke mefuta e sa tšoaneng ea mafu:
- collagenoses (dermatomyositis, systemic lupus erythematosus kapa scleroderma );
- lefu la kankere ea mali e sa foleng le e matla haholo (Waldenstrom macroglobulinemia, myeloma);
- mafu a liphio le lefu la sebete le sa foleng.
Haeba lefu lena le iponahatsa e le lefu le ka thōko, joale le bitsoa lefu la Verlhof, hammoho le lefuba la bohlokoa le la bohlokoa. Lisosa tsa lefu lena ha li hlahe hantle. Har'a lintho tse fetileng ho nts'etsopele ea eona, ho na le tšoaetso ea kokoana-hloko le libaktheria, ts'ebetso ea ho buoa, liente, likotsi le ho kenyelletsa gamma globulin. Ka liphesente tse 45%, thrombocytopiaa e hlokahalang e hlaha ka boomo ntle le mabaka.
Lisosa tsa tlhahiso e ntle ea thrombocytopenia
Thrombocytopenia e hlahisoang e hlaha 'meleng, ha mofu oa masapo o sa khone ho beha liplatelete ka chelete eo e hlokahalang bakeng sa potoloho e tloaelehileng. Lisosa tsa thrombocytopia ena ho batho ba baholo ke:
- lefu la khaello ea mali ;
- TAP-syndrome;
- myelodysplastic syndrome;
- myelosclerosis;
- metastases ea li-tumor tse ling lerung la masapo;
- ketso ea lik'hemik'hale (mohlala, benzene).
Ho phaella moo, thrombocytopiaa e hlahisoang e hlahisa litholoana tse bakoang ke kankere ea mali, ha ho na le hlahala e tebileng ea phetoho ea hematopoiesis, le bothata ba joala le mafu a sa tšoaneng (viremia, lefu la lefuba, malaria). Tloaelloa ke ho hloka li-platelet le ba nang le khaello ea vithamine B12 le folic acid. Phetoho e ka khoneha ea thrombocytopenia le khahlanong le phekolo ea radiation kapa ho pepesehela mahlaseli a ionyang.
Lisosa tsa lithethefatsi thrombocytopenia
Ka li-drug thrombocytopenia, li-antibodies li hlahisoa khahlanong le lithethefatsi tse ling tsa antigen tse ling tse emisitsoeng holim'a lilatelete, kapa ha sebopeho sa antigenic sa liplatelete se fetoha. Maemong a mangata, lisosa tsa mofuta ona oa thrombocytopenia ke lithethefatsi tse latelang:
1. Boits'oaro:
- Meprobamate;
- Phenobarbital;
- Sedormid;
- allyl isopropylbarbituric acid.
2. Alkaloids:
- Quinidine;
- Quinine.
- Likokoana-hloko;
- Oxytetracycline;
- Streptomycin;
- Chloramphenicol;
- Ristocetin.
3. Antibacterial sulfonamide:
- Sulfidiazine;
- Sulfamethazine.
4. Meriana e meng:
- Dinitrophenol;
- iodide ea potassium;
- Digitoxin;
- Carbamazepine.
Lisosa tsa thrombocytopenia ho bakuli ba HIV
Thrombocytopenia e ka hlahisa batho ba nang le tšoaetso ea HIV. Ho na le mabaka a mabeli a ho tsosa boemo bona ho bakuli:
- Ntlha ea pele, ke hore HIV e hlasela megakaryocytes, e bakang khaello ea liplatelete.
- Ea bobeli, lithethefatsi tse thusang ho loantša tšoaetso hangata li senya mofu o mofubelu oa motho.