Lihlahisoa tsa mosebetsi oa li-mushroom, tse nang le bokhoni ba ho loantša likokoana-hloko tse ling, li bitsoa lithibela-mafu. Ka lebaka la mosebetsi o tsoetseng pele oa likokoana-hloko le ho se be le phello e mpe bathong, lithibela-mafu tsa beta-lactam li sebelisoa ka ho feletseng phekolo ea likokoana-hloko, e fetohileng mokhoa o ka sehloohong oa phekolo ea mafu.
Mochine oa liketso tsa lithibela-mafu tsa beta-lactam
Tšobotsi e ka sehloohong ea lithethefatsi tsena ke ho ba teng ha lesale la beta-lactam, le khethollang mosebetsi oa bona. Sepheo se ka sehloohong se reretsoe ho etsa li-link tse pakeng tsa likokoana-hloko tse nyenyane tse ikarabellang bakeng sa ho thehoa ha leseli le ka ntle, le limolek'hule tsa penicillin le mefuta e meng ea lithibela-mafu. Likamano tse matla li tlatsetsa khatellong ea mosebetsi oa likokoana-hloko, ho fela ha tsoelo-pele ea bona, e qetellang e lebisa lefung.
Kemiso ea lithibela-mafu tsa beta-lactam
Ho na le lihlopha tse 'nè tse ka sehloohong tsa lithethefatsi tsa lithibela-mafu
1. Penicillin , e leng lihlahisoa tsa phapanyetsano ea mefuta e sa tšoaneng ea li-fentillium li-fungus. Ho ea ka tšimoloho ea bona ba tlhaho ebile ha ba na li-synthetic. Sehlopha sa pele se arotsoe ka bicillins le benzylpenicillins. Ea bobeli, lithibela-mafu tsa lihlopha tsa beta-lactam li khetholloa:
- Ampicillin, e tsebahalang e le mokhoa oa liketso tse ngata;
- Oxacillin, Methicillin - lithethefatsi, phello ea eona e na le tlhokomelo e fokolang;
- ureidopenicillins, e senyehileng ke beta-lactases (Piperacillin, Azlocillin);
- Li-penicilla tse nang le matla, tse nang le beta-lactamase inhibitors (tazoctam, clavulanic acid), e thibelang ho timetsoa ha moemeli ka libaktheria ( Amoxiclav , Unazin, Sulacilin, Augmentin).
2. Cephalosporins e hlahisoang ke li-fungus Cephalosporium li hanyetsana haholo le beta-lactamase ho feta sehlopha se fetileng. Ho na le lithibela-mafu tse joalo tsa beta-lactam:
- Cephaloridine;
- Ceforaxime;
- Cefotaxime ;
- Tšoaea.
3. Monobactam , e kenyeletsang Azrethon. Lithethefatsi tsena li na le likarolo tse fokolang, kaha ha li sebetse ho laola strepto- le staphylococci. Ka lebaka leo, li laeloa, haholo-holo khahlanong le li-fung tse gram-negative. Hangata li-Azthreon li fuoa lingaka haeba li se na mamello ho penicillin.
4. Carbapanemes , eo baemeli ba eona e leng Meropenem le Impenem, ke litho tsa mekhoa e mengata e nang le liphello tse kholo ka ho fetisisa. Meropenem e sebelisoa bakeng sa mekhoa e tšoaetsanoang e matla haholo, le haeba ho se na ntlafatso ea ho noa meriana e meng.